Investors / United States / 5AM Ventures
5AM Ventures
Venture capital · San Francisco, CA, United States · North America
5AM Ventures is a life science venture capital firm founded in 2002 that funds and builds next-generation life sciences companies. It invests primarily in private therapeutic companies, typically early-stage with an emphasis on Series A, and also runs a strategy investing in small and mid-cap public and later-stage private biotech and life science companies.
Invests inHealthcare & Biotech
In its own wordslife sciencesbiotechbiopharmaceuticalsdrug deliverytherapeuticshealthcare
Your fit with 5AM Ventures
Four questions about your startup
See how your round matches what it backs, point by point.
Or find every investor that fits5AM Ventures lists 50 checked portfolio companies on its own site and is named in 10 funding rounds, 3 of them as lead. Its most frequent entry is Series B, 44% of the companies with a known first round. Its largest themes are Healthcare & Biotech (77%), AI & Machine Learning (11%) and Fintech (4%). 88% of its companies are based in United States. It invests most often alongside RA Capital, Atlas Venture and DCVC.
Counts come from funding rounds that name 5AM Ventures, complete from mid-2025: earlier rounds appear only when they were reported later. Round amounts and full round histories are on Fundup AI.
Round figures show recent activity, not 5AM Ventures' whole history. Rounds on record name 10 companies; its own site lists 50. Funding rounds are complete from mid-2025, so counts and the yearly trend undercount a firm that invested before then. The portfolio, themes and places come from its own site and are not affected.
Entry stage
share of companies by the stage of its first roundShow as a table
| Value | |
|---|---|
| Pre-seed | 0% |
| Seed | 11% |
| Series A | 22% |
| Series B | 44% |
| Growth | 22% |
Activity by year
rounds it joined, last 10 yearsShow as a table
| Total | Rounds it led | |
|---|---|---|
| '17 | 0 | 0 |
| '18 | 0 | 0 |
| '19 | 0 | 0 |
| '20 | 0 | 0 |
| '21 | 0 | 0 |
| '22 | 1 | 1 |
| '23 | 0 | 0 |
| '24 | 0 | 0 |
| '25 | 5 | 2 |
| '26 | 4 | 0 |
Investor profile
percentile among all firmsShow as a table
| Measure | Percentile of all firms | Value |
|---|---|---|
| Portfolio size | 84th | 50 companies |
| Recent activity | 86th | 5 rounds in 12 months |
| Early stage | 55th | 11% of entries at pre-seed or seed |
| Evidence | 81th | 12% of companies confirmed by a round |
| Sector focus | 93th | 77% in its largest sector |
| Reach | 70th | 4 countries |
Investment themes
share of its checked companiesThis firmAll checked companies
Show as a table
| This firm | All checked companies | |
|---|---|---|
| Healthcare & Biotech | 77% | 15% |
| AI & Machine Learning | 11% | 18% |
| Fintech | 4% | 12% |
| Cybersecurity | 2% | 4% |
| Education | 2% | 7% |
| Robotics & Hardware | 2% | 1% |
| Food & Agriculture | 2% | 3% |
| E-commerce & Marketplaces | 2% | 6% |
Invests most often with
firms sharing its portfolio companiesShow as a table
| Share | |
|---|---|
| RA Capital | 7 |
| Atlas Venture | 5 |
| DCVC | 4 |
| Sanofi Ventures | 4 |
| Versant Ventures | 4 |
| Canaan | 3 |
| Catalio Capital Management | 3 |
| Frazier Life Sciences | 3 |
Its portfolio companies
where they are based, and what their own sites showSite status
- Site answers4998%
- No longer answers00%
- Points to another company12%
- Parked or sold domain00%
A site that stops answering three checks in a row is counted as no longer answering; that is not proof of closure. A site that points to another company is often an acquisition.
Co-investor network
who it backs companies with, and who they back togetherCompare 5AM Ventures head to head
portfolio size, rounds, entry stages, themes and the companies both backThree or more firms at once: portfolio overlap.
Recent portfolio activity
when companies last raised with 5AM Ventures| Date | Company | Stage |
|---|---|---|
| 19 Oct 2026 | Series C+ | |
| 23 Jan 2026 | Series A | |
| 12 Jan 2026 | Series B | |
| 10 Jan 2026 | Series B | |
| 11 Dec 2025 | Series A Led | |
| 18 Nov 2025 | Series B | |
| 22 Sept 2025 | Round | |
| 28 Jul 2025 | Series C+ |
Round details for 5AM Ventures
Amounts, full round histories and every co-investor in 5AM Ventures' rounds are on Fundup AI. VCinfo covers investors and their portfolios.
Portfolio
50 companies checked against their own sites| Company | What it does | Themes | First round with it | Evidence |
|---|---|---|---|---|
| Portfolio page | ||||
| Alexza Pharmaceuticals develops and commercializes pharmaceutical products, including Adasuve. | Healthcare & Biotech | Portfolio page | ||
| Aprea Therapeutics is a biopharmaceutical company focused on developing novel DDR targeted cancer therapeutics. | Healthcare & Biotech | Portfolio page | ||
| Artiva Biotherapeutics is developing therapies for autoimmune diseases, including a natural killer cell therapy called AlloNK | Healthcare & Biotech | Portfolio page | ||
| Arvinas develops targeted protein degradation therapeutics for serious diseases, particularly in neurology and oncology. | Healthcare & Biotech | Portfolio page | ||
| The company provides a search engine for scientific experimentation and tools for scientific suppliers | Healthcare & BiotechAI & Machine Learning | Portfolio page | ||
| Cabaletta Bio develops T cell therapies to treat autoimmune diseases | Healthcare & Biotech | Portfolio page | ||
| CAMP4 Therapeutics develops RNA therapeutics to restore healthy protein levels | Healthcare & Biotech | Portfolio page | ||
| Crinetics Pharmaceuticals is a company that develops and commercializes therapies, particularly for endocrine diseases. | Healthcare & Biotech | Portfolio page | ||
| Deverra Therapeutics is dedicated to developing allogeneic universal donor cellular immunotherapies that are cost effective and accessible to all patients. | Healthcare & Biotech | Portfolio page | ||
| Dianthus buys, boosts and builds businesses with AI | E-commerce & MarketplacesAI & Machine Learning | Portfolio page | ||
| Dianthus Therapeutics is developing potentially best in class therapies for patients living with severe autoimmune diseases. | Healthcare & Biotech | Portfolio page | ||
| Enliven Therapeutics develops small molecule kinase inhibitors for various diseases, including cancer. | Healthcare & Biotech | Portfolio page | ||
| Ensoma is an in vivo hematopoietic stem cell engineering company that creates a new kind of genomic medicine for patients around the world. | Healthcare & Biotech | Sept 2025Round | Page + round | |
| Entrada Therapeutics is working to treat devastating diseases with intracellular therapeutics | Healthcare & Biotech | Portfolio page | ||
| Envoy provides a workplace and visitor solutions platform | EducationHealthcare & Biotech | Portfolio page | ||
| Epirus develops and provides products to defend against autonomous drone attacks | AI & Machine LearningCybersecurity | Portfolio page | ||
| Flexion develops a unified foundation model that combines command, motion, and control for robots, trained in simulation and deployable across various robot morphologies. | AI & Machine LearningRobotics & Hardware | Portfolio page | ||
| Fortius Metals develops and sells welding wire for large format metal 3D printing and robotic welding | AI & Machine LearningAI & Machine Learning | Dec 2022Seed | Funding round | |
| GlycoEra develops biologics to selectively target and degrade specific circulating proteins that drive diseases such as autoantibodies in immune-driven disorders | Healthcare & Biotech | Portfolio page |
About this data
site last read 5 Nov 2026- Site
- 5amventures.com
- Last read
- 5 Nov 2026
- Watching since
- 5 Nov 2026
- Rounds since
- 6 Dec 2022
- Companies checked
- 50
Rates come from what VCinfo has observed since observation_start. Firms tend to remove companies that closed, so early rates understate reality. A company leaving a portfolio page does not mean it closed or exited. An unreachable site means our checks failed, nothing more.
Get 5AM Ventures' profile as data
Pull 5AM Ventures' portfolio, co-investors and changes through one API key or MCP, open every portfolio row, compare it with other firms, and get an email when it adds a company or files a fund.
Work email, sign-in link by email. Already have an account? Log in- Ask AI5 plain-English investor searches a day
- Full listsEvery portfolio row and two-firm overlap
- API and MCP100 REST or MCP calls a month, one key
- AlertsFollow 5 investors for portfolio and fund changes
$ curl -H "X-API-Key: YOUR_KEY" \
https://api.vcinfo.io/v1/firms/5amventures.com
# also
GET /v1/firms/5amventures.com/portfolio
GET /v1/firms/5amventures.com/coinvestors
GET /v1/firms/5amventures.com/news