Investors / United States / 645 Ventures
645 Ventures
Venture capital · New York, NY, United States · North America
645 Ventures is an early-stage venture capital firm based in New York and San Francisco. It invests in founders at the earliest stages, including pre-product and pre-revenue companies, and supports them through later fundraising.
Invests inAI & Machine Learning
In its own wordsenterprisedeep techai infrastructurefintechconsumercybersecurity
Your fit with 645 Ventures
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Or find every investor that fits645 Ventures lists 81 checked portfolio companies on its own site and is named in 25 funding rounds, 5 of them as lead. Its most frequent entry is Series A, 46% of the companies with a known first round. Its largest themes are AI & Machine Learning (30%), Fintech (12%) and Cybersecurity (9%). 90% of its companies are based in United States. It invests most often alongside Y Combinator, Andreessen Horowitz and Capital Factory.
Counts come from funding rounds that name 645 Ventures, complete from mid-2025: earlier rounds appear only when they were reported later. Round amounts and full round histories are on Fundup AI.
Round figures show recent activity, not 645 Ventures' whole history. Rounds on record name 24 companies; its own site lists 81. Funding rounds are complete from mid-2025, so counts and the yearly trend undercount a firm that invested before then. The portfolio, themes and places come from its own site and are not affected.
Entry stage
share of companies by the stage of its first roundShow as a table
| Value | |
|---|---|
| Pre-seed | 0% |
| Seed | 38% |
| Series A | 46% |
| Series B | 8% |
| Growth | 8% |
Activity by year
rounds it joined, last 10 yearsShow as a table
| Total | Rounds it led | |
|---|---|---|
| '17 | 0 | 0 |
| '18 | 1 | 0 |
| '19 | 0 | 0 |
| '20 | 0 | 0 |
| '21 | 0 | 0 |
| '22 | 0 | 0 |
| '23 | 0 | 0 |
| '24 | 2 | 1 |
| '25 | 6 | 2 |
| '26 | 16 | 2 |
Investor profile
percentile among all firmsShow as a table
| Measure | Percentile of all firms | Value |
|---|---|---|
| Portfolio size | 93th | 81 companies |
| Recent activity | 98th | 17 rounds in 12 months |
| Early stage | 65th | 38% of entries at pre-seed or seed |
| Evidence | 87th | 16% of companies confirmed by a round |
| Sector focus | 53th | 30% in its largest sector |
| Reach | 78th | 5 countries |
Investment themes
share of its checked companiesThis firmAll checked companies
Show as a table
| This firm | All checked companies | |
|---|---|---|
| AI & Machine Learning | 30% | 18% |
| Fintech | 12% | 12% |
| Cybersecurity | 9% | 4% |
| Enterprise Software | 9% | 8% |
| Healthcare & Biotech | 7% | 15% |
| Education | 6% | 7% |
| E-commerce & Marketplaces | 5% | 6% |
| Media & Entertainment | 4% | 4% |
Invests most often with
firms sharing its portfolio companiesShow as a table
| Share | |
|---|---|
| Y Combinator | 11 |
| Andreessen Horowitz | 4 |
| Capital Factory | 4 |
| 359 Capital | 3 |
| Correlation Ventures | 3 |
| Eniac Ventures | 3 |
| Glynn Capital | 3 |
| Green Visor Capital | 3 |
Its portfolio companies
where they are based, and what their own sites showSite status
- Site answers7998%
- No longer answers00%
- Points to another company22%
- Parked or sold domain00%
A site that stops answering three checks in a row is counted as no longer answering; that is not proof of closure. A site that points to another company is often an acquisition.
Co-investor network
who it backs companies with, and who they back togetherCompare 645 Ventures head to head
portfolio size, rounds, entry stages, themes and the companies both backThree or more firms at once: portfolio overlap.
Recent portfolio activity
when companies last raised with 645 Ventures| Date | Company | Stage |
|---|---|---|
| 9 Nov 2026 | Series A | |
| 27 Oct 2026 | Series A | |
| 9 Sept 2026 | Seed | |
| 4 Sept 2026 | Series B | |
| 4 Aug 2026 | Seed | |
| 30 Jul 2026 | Seed | |
| 15 Jun 2026 | Seed Led | |
| 1 Jun 2026 | Series A |
Round details for 645 Ventures
Amounts, full round histories and every co-investor in 645 Ventures' rounds are on Fundup AI. VCinfo covers investors and their portfolios.
Portfolio
81 companies checked against their own sites| Company | What it does | Themes | First round with it | Evidence |
|---|---|---|---|---|
| Agency builds custom AI agents that work 24/7/365 for companies | AI & Machine Learning | Portfolio page | ||
| Aiva provides a system to connect and manage hotel data and guest requests | Legal & ComplianceReal Estate & Construction | Jun 2026Seed | Funding round | |
| The company provides service on demand technology for hospitality. | Healthcare & Biotech | Portfolio page | ||
| Andrena provides high-speed internet services to residents, buildings, and businesses. | Enterprise SoftwareConsumer | Portfolio page | ||
| Portfolio page | ||||
| Apty provides a digital adoption platform for enterprise software to improve how work gets done inside applications | Enterprise SoftwareAI & Machine Learning | Portfolio page | ||
| Aryeo provides a platform for real estate photographers to manage their business and deliver media to clients | Real Estate & ConstructionMedia & Entertainment | Portfolio page | ||
| BeFreed provides a microlearning app that offers daily insights from books and other sources in a chosen voice and style | EducationMedia & Entertainment | Portfolio page | ||
| Portfolio page | ||||
| Besxar manufactures advanced semiconductor substrates, epitaxial layers, and thin-films in space | AI & Machine LearningAI & Machine Learning | Sept 2026Seed | Funding round | |
| Betterview provides insurance property intelligence software | FintechReal Estate & Construction | Portfolio page | ||
| Bigeye provides a data observability and AI trust platform for responsible enterprise AI | AI & Machine LearningEnterprise Software | Portfolio page | ||
| Causely provides causal intelligence for AI agents to diagnose and resolve incidents in systems. | AI & Machine LearningCybersecurity | Portfolio page | ||
| Circeus acquires and evolves mission-critical software | AI & Machine LearningEnterprise Software | Portfolio page | ||
| Clerq helps businesses accept payments directly from customers' bank accounts | FintechE-commerce & Marketplaces | Oct 2025Series A | Page + round | |
| Condor develops and provides software for managing clinical trial finances and operations in the biopharma industry | Healthcare & BiotechFintech | Mar 2026Series A | Page + round | |
| Cotiss reads and processes business data to provide insights and automate actions | Enterprise SoftwareFintech | Portfolio page | ||
| Crescendo Health helps participants in clinical studies assemble the story of their health and contribute it to medical research, while protecting their privacy. | Healthcare & Biotech | Portfolio page | ||
| Cube Dev provides a business intelligence platform built on a semantic layer for both humans and AI agents | AI & Machine LearningEnterprise Software | Portfolio page | ||
| DeepSource automates code reviews, so you can ship to production faster with confidence. | AI & Machine LearningCybersecurity | Portfolio page |
About this data
site last read 5 Nov 2026- Site
- 645ventures.com
- Last read
- 5 Nov 2026
- Watching since
- 5 Nov 2026
- Rounds since
- 14 Feb 2018
- Companies checked
- 81
Rates come from what VCinfo has observed since observation_start. Firms tend to remove companies that closed, so early rates understate reality. A company leaving a portfolio page does not mean it closed or exited. An unreachable site means our checks failed, nothing more.
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