Investors / United States / Apple Tree Partners
Apple Tree Partners
Venture capital · New York, NY, United States · North America
Apple Tree Partners is a life sciences venture capital firm founded in 1999. It creates and invests in biotechnology companies, from pre-IP ideas and asset spinouts to seed stage through IPO and beyond.
Invests inHealthcare & Biotech
In its own wordslife sciencesbiotechnologyventure capitalcompany creationtherapeutics
Your fit with Apple Tree Partners
Four questions about your startup
See how your round matches what it backs, point by point.
Or find every investor that fitsApple Tree Partners lists 18 checked portfolio companies on its own site and is named in 1 funding round. Its most frequent entry is Growth, 100% of the companies with a known first round. Its largest theme is Healthcare & Biotech (100%). 91% of its companies are based in United States. It invests most often alongside Sofinnova Partners, 8VC and Altamont Pharmaceutical Holdings.
Counts come from funding rounds that name Apple Tree Partners, complete from mid-2025: earlier rounds appear only when they were reported later. Round amounts and full round histories are on Fundup AI.
Round figures show recent activity, not Apple Tree Partners' whole history. Rounds on record name 1 company; its own site lists 18. Funding rounds are complete from mid-2025, so counts and the yearly trend undercount a firm that invested before then. The portfolio, themes and places come from its own site and are not affected.
Entry stage
share of companies by the stage of its first roundShow as a table
| Value | |
|---|---|
| Pre-seed | 0% |
| Seed | 0% |
| Series A | 0% |
| Series B | 0% |
| Growth | 100% |
Activity by year
rounds it joined, last 10 yearsShow as a table
| Total | Rounds it led | |
|---|---|---|
| '17 | 0 | 0 |
| '18 | 0 | 0 |
| '19 | 0 | 0 |
| '20 | 0 | 0 |
| '21 | 0 | 0 |
| '22 | 0 | 0 |
| '23 | 0 | 0 |
| '24 | 0 | 0 |
| '25 | 1 | 0 |
| '26 | 0 | 0 |
Investor profile
percentile among all firmsShow as a table
| Measure | Percentile of all firms | Value |
|---|---|---|
| Portfolio size | 46th | 18 companies |
| Recent activity | 46th | 0 rounds in 12 months |
| Early stage | 54th | 0% of entries at pre-seed or seed |
| Evidence | 65th | 6% of companies confirmed by a round |
| Sector focus | 100th | 100% in its largest sector |
| Reach | 42th | 2 countries |
Invests most often with
firms sharing its portfolio companiesShow as a table
| Share | |
|---|---|
| Sofinnova Partners | 2 |
| 8VC | 1 |
| Altamont Pharmaceutical Holdings | 1 |
| Atlas Venture | 1 |
| Boxer Capital | 1 |
| Elevage Medical Technologies | 1 |
| Elevate Ventures | 1 |
| Foresite Capital | 1 |
Its portfolio companies
where they are based, and what their own sites showSite status
- Site answers1794%
- No longer answers00%
- Points to another company16%
- Parked or sold domain00%
A site that stops answering three checks in a row is counted as no longer answering; that is not proof of closure. A site that points to another company is often an acquisition.
Investment themes
share of its checked companiesThis firmAll checked companies
Show as a table
| This firm | All checked companies | |
|---|---|---|
| Healthcare & Biotech | 100% | 15% |
Co-investor network
who it backs companies with, and who they back togetherAll co-investors or Compare portfolios with Sofinnova Partners
Compare Apple Tree Partners head to head
portfolio size, rounds, entry stages, themes and the companies both backThree or more firms at once: portfolio overlap.
Recent portfolio activity
when companies last raised with Apple Tree Partners| Date | Company | Stage |
|---|---|---|
| 3 Sept 2025 | Series C+ |
Round details for Apple Tree Partners
Amounts, full round histories and every co-investor in Apple Tree Partners' rounds are on Fundup AI. VCinfo covers investors and their portfolios.
Portfolio
18 companies checked against their own sites| Company | What it does | Themes | First round with it | Evidence |
|---|---|---|---|---|
| Aethon Therapeutics engineers novel antibodies, customized to be used in combination with targeted therapies to selectively kill drug-resistant cancer cells. | Healthcare & Biotech | Portfolio page | ||
| Akero Therapeutics is pioneering novel therapies to transform the lives of people living with serious metabolic diseases | Healthcare & Biotech | Portfolio page | ||
| Apertor creates novel molecular glues for therapeutic applications in oncology. | Healthcare & Biotech | Portfolio page | ||
| Ascidian Therapeutics is redefining the treatment of disease by rewriting RNA | Healthcare & Biotech | Portfolio page | ||
| Aulos Bioscience is developing an immune-activating antibody therapeutic to treat cancer | Healthcare & Biotech | Portfolio page | ||
| Braeburn strives to help those who need it most, particularly in relation to opioid use disorder. | Healthcare & Biotech | Portfolio page | ||
| Deep Apple Therapeutics is discovering new small-molecule therapeutics with unprecedented speed and exceptional acumen | Healthcare & Biotech | Portfolio page | ||
| Evercrisp Biosciences innovates at the molecular level to enable precise, safe, and scalable delivery of genetic therapies into target tissues | Healthcare & Biotech | Portfolio page | ||
| Galvanize Therapeutics designs pulsed electric field energy devices to address disease and restore function. | Healthcare & Biotech | Sept 2025Series C+ | Page + round | |
| Initial Therapeutics is pioneering an original mode of disease intervention by selectively terminating protein synthesis in the exit tunnel of the ribosome | Healthcare & Biotech | Portfolio page | ||
| Portfolio page | ||||
| Marengo Therapeutics develops novel TCR-targeting antibodies to combat cancer and other diseases | Healthcare & Biotech | Portfolio page | ||
| The company provides health technology for the digital age | Healthcare & Biotech | Portfolio page | ||
| Nereid Therapeutics develops therapeutics that can modify the phase behavior of living cells using physics and cell biology | Healthcare & Biotech | Portfolio page | ||
| Nine Square Therapeutics is accelerating the development of better drugs for better targets in a quest to alter the trajectory of neurodegenerative disease. | Healthcare & Biotech | Portfolio page | ||
Healthcare & Biotech | Portfolio page | |||
| Red Queen Therapeutics is a clinical-stage company working to deliver treatment options for a broad range of virus-borne illnesses | Healthcare & Biotech | Portfolio page | ||
| Replicate Bioscience is advancing a pipeline of self-replicating RNA treatments for various therapeutic areas | Healthcare & Biotech | Portfolio page |
About this data
site last read 5 Nov 2026- Site
- appletreepartners.com
- Last read
- 5 Nov 2026
- Watching since
- 6 Nov 2026
- Rounds since
- 3 Sept 2025
- Companies checked
- 18
Rates come from what VCinfo has observed since observation_start. Firms tend to remove companies that closed, so early rates understate reality. A company leaving a portfolio page does not mean it closed or exited. An unreachable site means our checks failed, nothing more.
Get Apple Tree Partners' profile as data
Pull Apple Tree Partners' portfolio, co-investors and changes through one API key or MCP, open every portfolio row, compare it with other firms, and get an email when it adds a company or files a fund.
Work email, sign-in link by email. Already have an account? Log in- Ask AI5 plain-English investor searches a day
- Full listsEvery portfolio row and two-firm overlap
- API and MCP100 REST or MCP calls a month, one key
- AlertsFollow 5 investors for portfolio and fund changes
$ curl -H "X-API-Key: YOUR_KEY" \
https://api.vcinfo.io/v1/firms/appletreepartners.com
# also
GET /v1/firms/appletreepartners.com/portfolio
GET /v1/firms/appletreepartners.com/coinvestors
GET /v1/firms/appletreepartners.com/news