Investors / Canada / Creative Destruction Lab
Creative Destruction Lab
Accelerator · Toronto, ON, Canada · North America
Creative Destruction Lab is a nonprofit organization that runs an objectives-based program for seed-stage, science- and technology-based companies. It operates 23 program streams across 17 locations globally, using mentoring from entrepreneurs, angel investors, economists and scientists.
Invests inAI & Machine LearningHealthcare & Biotech
In its own wordsscience-basedtechnologyseed-stagementorshipdeep techhealthcare
Your fit with Creative Destruction Lab
Four questions about your startup
See how your round matches what it backs, point by point.
Or find every investor that fitsCreative Destruction Lab lists 1,551 checked portfolio companies on its own site. Its largest themes are AI & Machine Learning (26%), Healthcare & Biotech (22%) and Industrial & Manufacturing (14%). 36% of its companies are based in United States. It invests most often alongside Y Combinator, SOSV and Techstars.
No funding round on record names Creative Destruction Lab yet, so the figures come from its portfolio page.
Round figures show recent activity, not Creative Destruction Lab's whole history. Rounds on record name 0 companies; its own site lists 1,551. Funding rounds are complete from mid-2025, so counts and the yearly trend undercount a firm that invested before then. The portfolio, themes and places come from its own site and are not affected.
Investment themes
share of its checked companiesThis firmAll checked companies
Show as a table
| This firm | All checked companies | |
|---|---|---|
| AI & Machine Learning | 26% | 18% |
| Healthcare & Biotech | 22% | 15% |
| Industrial & Manufacturing | 14% | 7% |
| Education | 5% | 7% |
| Fintech | 5% | 12% |
| Space & Defense | 4% | 3% |
| Cybersecurity | 4% | 4% |
| Enterprise Software | 4% | 8% |
Invests most often with
firms sharing its portfolio companiesShow as a table
| Share | |
|---|---|
| Y Combinator | 53 |
| SOSV | 41 |
| Techstars | 41 |
| IndieBio | 40 |
| Entrepreneurs First | 37 |
| Spring | 32 |
| Springboard | 21 |
| Accelerator Centre | 20 |
Investor profile
percentile among all firmsShow as a table
| Measure | Percentile of all firms | Value |
|---|---|---|
| Portfolio size | 100th | 1,551 companies |
| Recent activity | 46th | 0 rounds in 12 months |
| Early stage | 54th | 0% of entries at pre-seed or seed |
| Evidence | 52th | 0% of companies confirmed by a round |
| Sector focus | 38th | 26% in its largest sector |
| Reach | 100th | 46 countries |
Its portfolio companies
where they are based, and what their own sites showSite status
- Site answers1,50397%
- No longer answers00%
- Points to another company483%
- Parked or sold domain00%
A site that stops answering three checks in a row is counted as no longer answering; that is not proof of closure. A site that points to another company is often an acquisition.
Co-investor network
who it backs companies with, and who they back togetherCompare Creative Destruction Lab head to head
portfolio size, rounds, entry stages, themes and the companies both backThree or more firms at once: portfolio overlap.
Portfolio
1,551 companies checked against their own sites| Company | What it does | Themes | First round with it | Evidence |
|---|---|---|---|---|
| The company builds foundation models for laser processes that turn every laser into software — controllable, optimizable, and scalable | Industrial & Manufacturing | Portfolio page | ||
| 16-BIT develops AI-driven medical software for opportunistic screening and bone age assessment | Healthcare & Biotech | Portfolio page | ||
| 20/20 OptimEyes Technologies develops a drug delivery platform that delivers small-molecule drugs directly to mucosal surfaces | Healthcare & Biotech | Portfolio page | ||
| 2S Water Inc. provides real-time multimetal water analysis equipment and services. | Industrial & ManufacturingEnterprise Software | Portfolio page | ||
| Portfolio page | ||||
| The company produces high-performance biofibers that enable product developers to unlock new solutions | Healthcare & Biotech | Portfolio page | ||
| 3D Spark provides a manufacturing and procurement insights platform | Industrial & ManufacturingEnterprise Software | Portfolio page | ||
| 4D Surgical is developing a robotic treatment platform to access the brain for therapies and treatments. | Healthcare & Biotech | Portfolio page | ||
| The company detects wildfires using satellites and transmits early detection alerts in real-time. | AI & Machine LearningSpace & Defense | Portfolio page | ||
| The company supports the decisions that shape programs and portfolios in drug development using causal human biology tools anchored in human genetics and AI | Healthcare & Biotech | Portfolio page | ||
| The company develops wearable AI that converts human motion into digital commands to control smart devices. | Healthcare & BiotechAI & Machine Learning | Portfolio page | ||
| The company designs biologics to act more precisely where they are needed, aiming to improve both safety and efficacy. | Healthcare & Biotech | Portfolio page | ||
| A4i is a platform for supporting people with complex behavioural and mental health conditions. | Healthcare & Biotech | Portfolio page | ||
| A&K ROBOTICS develops and offers an AI-enabled micro-mobility pod for transportation in large venues. | Robotics & Hardware | Portfolio page | ||
| AAZZUR provides a platform for companies to launch financial products and services under their own brand | FintechFintech | Portfolio page | ||
| About:Energy provides a battery modelling and cell data platform | EducationIndustrial & Manufacturing | Portfolio page | ||
| Absco Therapeutics develops and applies thermogelling polymers for targeted and sustained drug delivery to combat cancer and other diseases. | Healthcare & Biotech | Portfolio page | ||
| Acceder engineers Specialized Intelligence Engines combining an organization's data, knowledge, business logic, analytical models, and AI to support better decisions. | AI & Machine LearningFintech | Portfolio page | ||
| Accipiter Biosciences designs and develops protein therapies to address complex diseases. | Healthcare & Biotech | Portfolio page | ||
| Acerta provides a manufacturing quality platform using AI to help manufacturers identify and resolve defects early | AI & Machine LearningIndustrial & Manufacturing | Portfolio page |
About this data
site last read 10 Nov 2026- Site
- creativedestructionlab.com
- Last read
- 10 Nov 2026
- Watching since
- 5 Nov 2026
- Companies checked
- 1,551
Rates come from what VCinfo has observed since observation_start. Firms tend to remove companies that closed, so early rates understate reality. A company leaving a portfolio page does not mean it closed or exited. An unreachable site means our checks failed, nothing more.
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