Investors / Australia / Main Sequence
Main Sequence
Venture capital · Australia · Asia Pacific
Main Sequence is a venture capital firm that invests in deep tech companies built on scientific research and difficult engineering. It was founded by CSIRO in 2017 to commercialise Australian publicly funded research and manages over $1 billion across its funds.
Invests inAI & Machine LearningIndustrial & Manufacturing
In its own wordsdeep techspacedecarbonisationhealthcareindustrial productivityresearch commercialisation
Your fit with Main Sequence
Four questions about your startup
See how your round matches what it backs, point by point.
Or find every investor that fitsMain Sequence lists 64 checked portfolio companies on its own site and is named in 20 funding rounds, 7 of them as lead. Its most frequent entry is Series A, 39% of the companies with a known first round. Its largest themes are AI & Machine Learning (32%), Industrial & Manufacturing (16%) and Healthcare & Biotech (11%). 84% of its companies are based in Australia. It invests most often alongside Breakthrough Victoria, Startmate and Uniseed.
Counts come from funding rounds that name Main Sequence, complete from mid-2025: earlier rounds appear only when they were reported later. Round amounts and full round histories are on Fundup AI.
Round figures show recent activity, not Main Sequence's whole history. Rounds on record name 19 companies; its own site lists 64. Funding rounds are complete from mid-2025, so counts and the yearly trend undercount a firm that invested before then. The portfolio, themes and places come from its own site and are not affected.
Entry stage
share of companies by the stage of its first roundShow as a table
| Value | |
|---|---|
| Pre-seed | 6% |
| Seed | 22% |
| Series A | 39% |
| Series B | 11% |
| Growth | 22% |
Activity by year
rounds it joined, last 10 yearsShow as a table
| Total | Rounds it led | |
|---|---|---|
| '17 | 0 | 0 |
| '18 | 0 | 0 |
| '19 | 0 | 0 |
| '20 | 0 | 0 |
| '21 | 0 | 0 |
| '22 | 0 | 0 |
| '23 | 1 | 0 |
| '24 | 0 | 0 |
| '25 | 6 | 1 |
| '26 | 13 | 6 |
Investor profile
percentile among all firmsShow as a table
| Measure | Percentile of all firms | Value |
|---|---|---|
| Portfolio size | 89th | 63 companies |
| Recent activity | 97th | 13 rounds in 12 months |
| Early stage | 61th | 28% of entries at pre-seed or seed |
| Evidence | 89th | 17% of companies confirmed by a round |
| Sector focus | 57th | 32% in its largest sector |
| Reach | 59th | 3 countries |
Investment themes
share of its checked companiesThis firmAll checked companies
Show as a table
| This firm | All checked companies | |
|---|---|---|
| AI & Machine Learning | 32% | 18% |
| Industrial & Manufacturing | 16% | 7% |
| Healthcare & Biotech | 11% | 15% |
| Education | 7% | 7% |
| Robotics & Hardware | 6% | 1% |
| Space & Defense | 6% | 3% |
| Cybersecurity | 6% | 4% |
| Food & Agriculture | 6% | 3% |
Invests most often with
firms sharing its portfolio companiesShow as a table
| Share | |
|---|---|
| Breakthrough Victoria | 8 |
| Startmate | 6 |
| Uniseed | 6 |
| Virescent Ventures | 6 |
| DCVC | 4 |
| IQT | 4 |
| InterValley Ventures | 4 |
| Possible Ventures | 4 |
Its portfolio companies
where they are based, and what their own sites showSite status
- Site answers64100%
- No longer answers00%
- Points to another company00%
- Parked or sold domain00%
A site that stops answering three checks in a row is counted as no longer answering; that is not proof of closure. A site that points to another company is often an acquisition.
Co-investor network
who it backs companies with, and who they back togetherAll co-investors or Compare portfolios with Breakthrough Victoria
Compare Main Sequence head to head
portfolio size, rounds, entry stages, themes and the companies both backThree or more firms at once: portfolio overlap.
Funds
from public registers and its siteRecent portfolio activity
when companies last raised with Main Sequence| Date | Company | Stage |
|---|---|---|
| 8 Oct 2026 | Series A | |
| 22 Sept 2026 | Series B Led | |
| 9 Sept 2026 | Pre-Seed Led | |
| 26 Aug 2026 | Seed Led | |
| 2 Jul 2026 | Series A | |
| 29 Apr 2026 | Seed Led | |
| 14 Apr 2026 | Seed Led | |
| 24 Mar 2026 | Series A Led |
Round details for Main Sequence
Amounts, full round histories and every co-investor in Main Sequence's rounds are on Fundup AI. VCinfo covers investors and their portfolios.
Portfolio
64 companies checked against their own sites| Company | What it does | Themes | First round with it | Evidence |
|---|---|---|---|---|
| Advanced Navigation designs and develops navigation systems for various industries and applications, including defense, heavy industry vehicles, and subsea navigation. | AI & Machine LearningAI & Machine Learning | Mar 2026Series C+ | Page + round | |
| Aigentsphere provides a platform for enterprises to manage and govern their AI workforce, offering features such as agent registration, performance management, and compliance governance. | AI & Machine LearningEnterprise Software | Apr 2026Seed | Funding round | |
| Amber provides renewable energy services, including wholesale electricity and battery automation, to residential customers. | EducationEducation | Portfolio page | ||
| Andromeda connects AI teams with high-performance compute | AI & Machine LearningCybersecurity | Portfolio page | ||
| The company develops and provides personalized robot companions for aged care and assisted living residents | Healthcare & BiotechRobotics & Hardware | Sept 2025Series A | Funding round | |
| Arlula automates how Earth observation data is discovered, tasked, sold, delivered, and governed – reliably and at scale with your existing systems. | Space & DefenseAI & Machine Learning | Portfolio page | ||
| Avarni provides carbon accounting software for compliance with regulations such as ASRS | FintechClimate & Energy | Portfolio page | ||
| Baraja is a deep technology company that has reinvented LiDAR for self-driving vehicles. | Mobility & LogisticsIndustrial & Manufacturing | Portfolio page | ||
| Breaker Industries develops software for voice-controlled robot teams | Robotics & HardwareAI & Machine Learning | Feb 2026Seed | Page + round | |
| Xylo provides an AI-powered workspace to help planning teams with administrative tasks and decision-making | AI & Machine LearningReal Estate & Construction | Portfolio page | ||
| Castlepoint automates records classification and provides data governance capabilities to help organizations manage information and risk | CybersecurityAI & Machine Learning | Portfolio page | ||
| Cauldron develops and uses biomanufacturing technology to produce various products, including food proteins and ingredients, materials, and fuels. | Healthcare & BiotechIndustrial & Manufacturing | Mar 2026Series A | Page + round | |
| Cortisonic builds machine-learning hardware from arrays of nanomechanical oscillators. | AI & Machine LearningRobotics & Hardware | Portfolio page | ||
| Portfolio page | ||||
| Currus Biologics is developing its proprietary BEAT technology for solid tumours | Healthcare & Biotech | Portfolio page | ||
| Cylite provides a product called HP-OCT | Healthcare & Biotech | Portfolio page | ||
| Deteqt develops and manufactures chip-scale quantum sensing platforms using diamond-on-chip technology for magnetic field-aware intelligence. | Industrial & ManufacturingAI & Machine Learning | Mar 2025Seed · 2 rounds | Page + round | |
| Diraq is building quantum computers using spin qubits based on modified silicon transistors | Healthcare & BiotechIndustrial & Manufacturing | Portfolio page | ||
| Eden Brew develops a nutrition delivery platform based on casein micelle functionality | Food & Agriculture | Portfolio page | ||
| ElectraLith extracts and refines lithium using its DLE-R technology | Industrial & ManufacturingClimate & Energy | Portfolio page |
About this data
site last read 13 Nov 2026- Site
- mseq.vc
- Last read
- 13 Nov 2026
- Watching since
- 5 Nov 2026
- Rounds since
- 31 Jul 2023
- Companies checked
- 64
Rates come from what VCinfo has observed since observation_start. Firms tend to remove companies that closed, so early rates understate reality. A company leaving a portfolio page does not mean it closed or exited. An unreachable site means our checks failed, nothing more.
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