Investors / United States / Route 66 Ventures
Route 66 Ventures
Venture capital · Alexandria, VA, United States · North America
Route 66 Ventures is an early-stage investor that provides capital and guidance to technology companies, with a focus on digital health and wellness and financial technology. The firm says it has performed 500+ transactions and deployed over $550M in capital since 2014, and typically makes initial investments of $500K to $4M.
Invests inHealthcare & BiotechFintech
In its own wordsdigital healthwellnessfintechfinancial servicesearly stage
Your fit with Route 66 Ventures
Four questions about your startup
See how your round matches what it backs, point by point.
Or find every investor that fitsRoute 66 Ventures lists 39 checked portfolio companies on its own site. Its largest themes are Healthcare & Biotech (39%), Fintech (29%) and AI & Machine Learning (10%). 63% of its companies are based in United States. It invests most often alongside Overlook Ventures, AV8 Ventures and Alpha Edison.
No funding round on record names Route 66 Ventures yet, so the figures come from its portfolio page.
Round figures show recent activity, not Route 66 Ventures' whole history. Rounds on record name 0 companies; its own site lists 39. Funding rounds are complete from mid-2025, so counts and the yearly trend undercount a firm that invested before then. The portfolio, themes and places come from its own site and are not affected.
Investment themes
share of its checked companiesThis firmAll checked companies
Show as a table
| This firm | All checked companies | |
|---|---|---|
| Healthcare & Biotech | 39% | 15% |
| Fintech | 29% | 12% |
| AI & Machine Learning | 10% | 18% |
| Space & Defense | 6% | 3% |
| Enterprise Software | 6% | 8% |
| Cybersecurity | 4% | 4% |
| Food & Agriculture | 2% | 3% |
| Consumer | 2% | 3% |
Invests most often with
firms sharing its portfolio companiesShow as a table
| Share | |
|---|---|
| Overlook Ventures | 3 |
| AV8 Ventures | 2 |
| Alpha Edison | 2 |
| Palo Santo | 2 |
| Remarkable Ventures | 2 |
| S2G Investments | 2 |
| Western Technology Investment | 2 |
| 1955 Capital | 1 |
Investor profile
percentile among all firmsShow as a table
| Measure | Percentile of all firms | Value |
|---|---|---|
| Portfolio size | 77th | 39 companies |
| Recent activity | 46th | 0 rounds in 12 months |
| Early stage | 54th | 0% of entries at pre-seed or seed |
| Evidence | 52th | 0% of companies confirmed by a round |
| Sector focus | 71th | 39% in its largest sector |
| Reach | 70th | 4 countries |
Its portfolio companies
where they are based, and what their own sites showSite status
- Site answers3897%
- No longer answers00%
- Points to another company13%
- Parked or sold domain00%
A site that stops answering three checks in a row is counted as no longer answering; that is not proof of closure. A site that points to another company is often an acquisition.
Co-investor network
who it backs companies with, and who they back togetherAll co-investors or Compare portfolios with Overlook Ventures
Compare Route 66 Ventures head to head
portfolio size, rounds, entry stages, themes and the companies both backThree or more firms at once: portfolio overlap.
Portfolio
39 companies checked against their own sites| Company | What it does | Themes | First round with it | Evidence |
|---|---|---|---|---|
| AccessPay provides bank integration solutions for secure and efficient payment processing | FintechSpace & Defense | Portfolio page | ||
| Accorded provides actuarial services and data analysis for health plans, ACOs, and risk-bearing providers | Healthcare & Biotech | Portfolio page | ||
| Auxira Health provides a virtual care team that handles routine follow-up visits and inbox management for cardiologists | Healthcare & Biotech | Portfolio page | ||
| Canvas Medical provides an AI-powered healthcare platform for clinics | Healthcare & Biotech | Portfolio page | ||
| Change Foods creates dairy foods using microbes instead of animals | Food & AgricultureHealthcare & Biotech | Portfolio page | ||
| Clearmatics builds peer-to-peer infrastructure for decentralized markets | Fintech | Portfolio page | ||
| Portfolio page | ||||
| D3 Technology builds small-to-medium scale applications for startups. | Enterprise SoftwareCybersecurity | Portfolio page | ||
| The company produces and sells laundry detergents and boosters. | Consumer | Portfolio page | ||
| DriveWealth provides a technology platform for companies to offer securities trading to their clients. | FintechHealthcare & Biotech | Portfolio page | ||
| EarthOptics combines advanced field sensors and lab analysis to deliver the most complete view of a soil's potential | AI & Machine LearningAI & Machine Learning | Portfolio page | ||
| Flume Health provides a secure AI platform for running a health plan | Healthcare & Biotech | Portfolio page | ||
| Gilgamesh Pharma develops innovative new chemical entities to transform the treatment paradigm of psychiatric disease | Healthcare & Biotech | Portfolio page | ||
| Portfolio page | ||||
| The company provides home care services for the elderly, including live-in care, companion care, and personal care. | Healthcare & Biotech | Portfolio page | ||
| Hydrogen provides a no-code technology platform for embedding financial services in businesses. | Fintech | Portfolio page | ||
| Hyphen connects individuals, teams, and partners to help succeed in projects. | AI & Machine LearningFintech | Portfolio page | ||
| Infrascale provides backup and disaster recovery solutions for various devices and systems. | CybersecuritySpace & Defense | Portfolio page | ||
| Joon provides therapy and counseling services for teens and young adults. | Healthcare & Biotech | Portfolio page | ||
| Judopay provides online payment solutions and services for businesses | Fintech | Portfolio page |
About this data
site last read 11 Nov 2026- Site
- route66ventures.com
- Last read
- 11 Nov 2026
- Watching since
- 7 Nov 2026
- Companies checked
- 39
Rates come from what VCinfo has observed since observation_start. Firms tend to remove companies that closed, so early rates understate reality. A company leaving a portfolio page does not mean it closed or exited. An unreachable site means our checks failed, nothing more.
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