Investors / United States / Upside Partnership
Upside Partnership
Venture capital · Mill Valley, CA, United States · North America
Upside Partnership is an early-stage investment firm that backs founders it calls "inevitable Founders." It typically makes an initial check of $500K and reserves 70% of its fund to support founders in later rounds.
Invests inSpace & DefenseHealthcare & BiotechAI & Machine Learning
In its own wordsearly-stagefounder-ledfollow-onfirst-institutional-investor
Your fit with Upside Partnership
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See how your round matches what it backs, point by point.
Or find every investor that fitsUpside Partnership lists 2 checked portfolio companies on its own site and is named in 3 funding rounds. Its most frequent entry is Series A, 67% of the companies with a known first round. Its largest themes are Space & Defense (50%), Healthcare & Biotech (25%) and AI & Machine Learning (25%). 100% of its companies are based in United States. It invests most often alongside Aspect Ventures, Casdin Capital and Harrison Metal.
Counts come from funding rounds that name Upside Partnership, complete from mid-2025: earlier rounds appear only when they were reported later. Round amounts and full round histories are on Fundup AI.
Entry stage
share of companies by the stage of its first roundShow as a table
| Value | |
|---|---|
| Pre-seed | 0% |
| Seed | 0% |
| Series A | 67% |
| Series B | 33% |
| Growth | 0% |
Activity by year
rounds it joined, last 10 yearsShow as a table
| Total | Rounds it led | |
|---|---|---|
| '17 | 1 | 0 |
| '18 | 0 | 0 |
| '19 | 0 | 0 |
| '20 | 0 | 0 |
| '21 | 1 | 0 |
| '22 | 0 | 0 |
| '23 | 0 | 0 |
| '24 | 0 | 0 |
| '25 | 0 | 0 |
| '26 | 1 | 0 |
Invests most often with
firms sharing its portfolio companiesShow as a table
| Share | |
|---|---|
| Aspect Ventures | 1 |
| Casdin Capital | 1 |
| Harrison Metal | 1 |
| K2 HealthVentures | 1 |
| Layout Ventures | 1 |
| OpAmp Capital | 1 |
| Operator Partners | 1 |
| Redpoint Ventures | 1 |
Its portfolio companies
where they are based, and what their own sites showSite status
- Site answers2100%
- No longer answers00%
- Points to another company00%
- Parked or sold domain00%
A site that stops answering three checks in a row is counted as no longer answering; that is not proof of closure. A site that points to another company is often an acquisition.
Investment themes
share of its checked companiesThis firmAll checked companies
Show as a table
| This firm | All checked companies | |
|---|---|---|
| Space & Defense | 50% | 3% |
| Healthcare & Biotech | 25% | 15% |
| AI & Machine Learning | 25% | 18% |
Co-investor network
who it backs companies with, and who they back togetherCompare Upside Partnership head to head
portfolio size, rounds, entry stages, themes and the companies both backThree or more firms at once: portfolio overlap.
Recent portfolio activity
when companies last raised with Upside Partnership| Date | Company | Stage |
|---|---|---|
| 8 Jan 2026 | Series B | |
| 10 Mar 2017 | Series A |
Round details for Upside Partnership
Amounts, full round histories and every co-investor in Upside Partnership's rounds are on Fundup AI. VCinfo covers investors and their portfolios.
Portfolio
2 companies checked against their own sites| Company | What it does | Themes | First round with it | Evidence |
|---|---|---|---|---|
| Apella provides ambient AI for operating rooms to optimize capacity, streamline coordination, and improve patient care. | Healthcare & BiotechAI & Machine Learning | Jan 2026Series B | Funding round | |
| Astro Technology extracts resources from the moon | Space & DefenseSpace & Defense | Mar 2017Series A | Funding round |
About this data
site last read 5 Nov 2026- Site
- upsidevc.com
- Last read
- 5 Nov 2026
- Watching since
- 6 Nov 2026
- Rounds since
- 10 Mar 2017
- Companies checked
- 2
Rates come from what VCinfo has observed since observation_start. Firms tend to remove companies that closed, so early rates understate reality. A company leaving a portfolio page does not mean it closed or exited. An unreachable site means our checks failed, nothing more.
Get Upside Partnership's profile as data
Pull Upside Partnership's portfolio, co-investors and changes through one API key or MCP, open every portfolio row, compare it with other firms, and get an email when it adds a company or files a fund.
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- Full listsEvery portfolio row and two-firm overlap
- API and MCP100 REST or MCP calls a month, one key
- AlertsFollow 5 investors for portfolio and fund changes
$ curl -H "X-API-Key: YOUR_KEY" \
https://api.vcinfo.io/v1/firms/upsidevc.com
# also
GET /v1/firms/upsidevc.com/portfolio
GET /v1/firms/upsidevc.com/coinvestors
GET /v1/firms/upsidevc.com/news