Investors / United States / Wireframe Ventures
Wireframe Ventures
Venture capital · San Francisco, CA, United States · North America
Wireframe Ventures is a seed-stage venture capital firm that invests early in startups, typically writing initial checks of $500K to $2M and often leading or joining syndicates. It works hands-on with founding teams toward product/market fit and an institutional Series A.
Invests inHealthcare & BiotechAI & Machine Learning
In its own wordsclimatebiotechhealthcareaiautomationenergy
Your fit with Wireframe Ventures
Four questions about your startup
See how your round matches what it backs, point by point.
Or find every investor that fitsWireframe Ventures lists 41 checked portfolio companies on its own site and is named in 6 funding rounds. Its most frequent entry is Seed, 100% of the companies with a known first round. Its largest themes are Healthcare & Biotech (24%), AI & Machine Learning (16%) and Education (13%). 88% of its companies are based in United States. It invests most often alongside Congruent Ventures, Elemental Impact and Crosslink Capital.
Counts come from funding rounds that name Wireframe Ventures, complete from mid-2025: earlier rounds appear only when they were reported later. Round amounts and full round histories are on Fundup AI.
Round figures show recent activity, not Wireframe Ventures' whole history. Rounds on record name 5 companies; its own site lists 41. Funding rounds are complete from mid-2025, so counts and the yearly trend undercount a firm that invested before then. The portfolio, themes and places come from its own site and are not affected.
Entry stage
share of companies by the stage of its first roundShow as a table
| Value | |
|---|---|
| Pre-seed | 0% |
| Seed | 100% |
| Series A | 0% |
| Series B | 0% |
| Growth | 0% |
Activity by year
rounds it joined, last 10 yearsShow as a table
| Total | Rounds it led | |
|---|---|---|
| '17 | 0 | 0 |
| '18 | 0 | 0 |
| '19 | 0 | 0 |
| '20 | 0 | 0 |
| '21 | 0 | 0 |
| '22 | 0 | 0 |
| '23 | 0 | 0 |
| '24 | 1 | 0 |
| '25 | 1 | 0 |
| '26 | 4 | 0 |
Investor profile
percentile among all firmsShow as a table
| Measure | Percentile of all firms | Value |
|---|---|---|
| Portfolio size | 77th | 40 companies |
| Recent activity | 82th | 4 rounds in 12 months |
| Early stage | 100th | 100% of entries at pre-seed or seed |
| Evidence | 71th | 8% of companies confirmed by a round |
| Sector focus | 30th | 24% in its largest sector |
| Reach | 58th | 3 countries |
Investment themes
share of its checked companiesThis firmAll checked companies
Show as a table
| This firm | All checked companies | |
|---|---|---|
| Healthcare & Biotech | 24% | 15% |
| AI & Machine Learning | 16% | 18% |
| Education | 13% | 7% |
| Industrial & Manufacturing | 10% | 7% |
| Space & Defense | 9% | 3% |
| Fintech | 5% | 12% |
| Cybersecurity | 5% | 4% |
| E-commerce & Marketplaces | 5% | 6% |
Invests most often with
firms sharing its portfolio companiesShow as a table
| Share | |
|---|---|
| Congruent Ventures | 5 |
| Elemental Impact | 5 |
| Crosslink Capital | 3 |
| Ulu Ventures | 3 |
| 8VC | 2 |
| AiSprouts VC | 2 |
| Bison Ventures | 2 |
| Buff Gold Ventures | 2 |
Its portfolio companies
where they are based, and what their own sites showSite status
- Site answers4098%
- No longer answers00%
- Points to another company12%
- Parked or sold domain00%
A site that stops answering three checks in a row is counted as no longer answering; that is not proof of closure. A site that points to another company is often an acquisition.
Co-investor network
who it backs companies with, and who they back togetherAll co-investors or Compare portfolios with Congruent Ventures
Compare Wireframe Ventures head to head
portfolio size, rounds, entry stages, themes and the companies both backThree or more firms at once: portfolio overlap.
Recent portfolio activity
when companies last raised with Wireframe Ventures| Date | Company | Stage |
|---|---|---|
| 30 Jun 2026 | Seed | |
| 18 Mar 2026 | Series A | |
| 13 Mar 2026 | Seed | |
| 12 Mar 2026 | Seed | |
| 2 Jul 2025 | Seed | |
| 8 Aug 2024 | Seed |
Round details for Wireframe Ventures
Amounts, full round histories and every co-investor in Wireframe Ventures' rounds are on Fundup AI. VCinfo covers investors and their portfolios.
Portfolio
41 companies checked against their own sites| Company | What it does | Themes | First round with it | Evidence |
|---|---|---|---|---|
| Altira Health helps health systems follow patients via voice and SMS, escalating to clinicians only when needed. | Healthcare & Biotech | Portfolio page | ||
| Applied Carbon converts crop residues into biochar using mobile technology and precision automation. | AI & Machine LearningAI & Machine Learning | Portfolio page | ||
| Arcturus develops advanced conductor materials by infusing carbon nanomaterials into metals to improve conductivity and strength at high temperatures. | Industrial & ManufacturingAI & Machine Learning | Jun 2026Seed | Page + round | |
| Argon Ai Inc provides an AI-powered workspace for life sciences teams to automate workflows and find answers | Healthcare & Biotech | Jul 2025Seed | Funding round | |
| Astronomer provides a platform to run Apache Airflow for data and AI orchestration | AI & Machine LearningCybersecurity | Portfolio page | ||
| Bedrock Energy provides geothermal heating and cooling systems for buildings using ground-source heat pumps. | EducationReal Estate & Construction | Portfolio page | ||
| Caladan develops and provides biomanufacturing technology and infrastructure powered by automation, sensors, and artificial intelligence. | Healthcare & Biotech | Portfolio page | ||
| Canopy Climate helps households plan and finance home upgrades such as heat pumps, rooftop solar, and electric vehicles to reduce energy consumption and costs. | EducationFintech | Portfolio page | ||
| Cocoon Carbon transforms the by-product of electric steelmaking into a low-carbon Supplementary Cementitious Material (SCM) called LoopCem | Industrial & ManufacturingSpace & Defense | Aug 2024Seed · 2 rounds | Page + round | |
| DNAnexus manages, analyzes and collaborates on large-scale multi-omic and clinical data. | Healthcare & Biotech | Portfolio page | ||
| Earnest RCM provides AI-powered revenue cycle management services to healthcare providers to help them get paid by insurance companies more efficiently. | Healthcare & Biotech | Portfolio page | ||
| Endpoint Health develops precision immunology therapies for immune-driven critical and chronic illnesses | Healthcare & Biotech | Portfolio page | ||
| Enveda is learning from life to discover medicines | Healthcare & Biotech | Portfolio page | ||
| Ezra helps companies raise debt and project finance by connecting them with lenders through their platform and deal team. | FintechReal Estate & Construction | Mar 2026Seed | Funding round | |
| Full Harvest builds an agentic intelligence layer to orchestrate the global food supply chain | AI & Machine LearningFood & Agriculture | Portfolio page | ||
| GeneSight analyzes how a person's genes may affect medication outcomes for psychiatric conditions | Healthcare & Biotech | Portfolio page | ||
| Geneticure develops a genomic platform to guide treatment decisions for high blood pressure patients, using genetic data to predict the effectiveness of renal denervation or medications. | Healthcare & Biotech | Portfolio page | ||
| Great Sky develops hardware and systems for artificial intelligence computing using physics-based approaches. | AI & Machine LearningCybersecurity | Mar 2026Seed | Page + round | |
| Gridware develops and provides a platform for electric utilities to detect hazards and manage their grid in real-time. | EducationHealthcare & Biotech | Portfolio page | ||
| LevelTen Energy is a platform where utility-scale clean energy gets bought and sold | EducationEducation | Portfolio page |
About this data
site last read 5 Nov 2026- Site
- wireframevc.com
- Last read
- 5 Nov 2026
- Watching since
- 5 Nov 2026
- Rounds since
- 8 Aug 2024
- Companies checked
- 41
Rates come from what VCinfo has observed since observation_start. Firms tend to remove companies that closed, so early rates understate reality. A company leaving a portfolio page does not mean it closed or exited. An unreachable site means our checks failed, nothing more.
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