Investors / United States / .406 Ventures
.406 Ventures
Venture capital · Boston, MA, United States · North America
.406 Ventures is a venture capital firm that partners with early-stage companies, first investing at seed and Series A financings and continuing to support them through their lifecycles. It focuses on healthcare, data and AI, and cybersecurity, and provides capital plus operational resources to founders.
Invests inHealthcare & BiotechAI & Machine Learning
In its own wordshealthcaredataaicybersecurityearly-stageb2b software
Your fit with .406 Ventures
Four questions about your startup
See how your round matches what it backs, point by point.
Or find every investor that fits.406 Ventures lists 67 checked portfolio companies on its own site and is named in 10 funding rounds, 3 of them as lead. Its most frequent entry is Series A, 67% of the companies with a known first round. Its largest themes are Healthcare & Biotech (32%), AI & Machine Learning (23%) and Enterprise Software (14%). 95% of its companies are based in United States. It invests most often alongside F-Prime Capital, Optum Ventures and Blue Venture Funds.
Counts come from funding rounds that name .406 Ventures, complete from mid-2025: earlier rounds appear only when they were reported later. Round amounts and full round histories are on Fundup AI.
Round figures show recent activity, not .406 Ventures' whole history. Rounds on record name 10 companies; its own site lists 67. Funding rounds are complete from mid-2025, so counts and the yearly trend undercount a firm that invested before then. The portfolio, themes and places come from its own site and are not affected.
Entry stage
share of companies by the stage of its first roundShow as a table
| Value | |
|---|---|
| Pre-seed | 0% |
| Seed | 11% |
| Series A | 67% |
| Series B | 0% |
| Growth | 22% |
Activity by year
rounds it joined, last 10 yearsShow as a table
| Total | Rounds it led | |
|---|---|---|
| '17 | 0 | 0 |
| '18 | 0 | 0 |
| '19 | 0 | 0 |
| '20 | 0 | 0 |
| '21 | 0 | 0 |
| '22 | 0 | 0 |
| '23 | 0 | 0 |
| '24 | 0 | 0 |
| '25 | 3 | 0 |
| '26 | 7 | 3 |
Investor profile
percentile among all firmsShow as a table
| Measure | Percentile of all firms | Value |
|---|---|---|
| Portfolio size | 90th | 67 companies |
| Recent activity | 93th | 8 rounds in 12 months |
| Early stage | 55th | 11% of entries at pre-seed or seed |
| Evidence | 84th | 13% of companies confirmed by a round |
| Sector focus | 58th | 32% in its largest sector |
| Reach | 42th | 2 countries |
Investment themes
share of its checked companiesThis firmAll checked companies
Show as a table
| This firm | All checked companies | |
|---|---|---|
| Healthcare & Biotech | 32% | 15% |
| AI & Machine Learning | 23% | 18% |
| Enterprise Software | 14% | 8% |
| Cybersecurity | 14% | 4% |
| Fintech | 8% | 12% |
| Education | 3% | 7% |
| Media & Entertainment | 2% | 4% |
| E-commerce & Marketplaces | 1% | 6% |
Invests most often with
firms sharing its portfolio companiesShow as a table
| Share | |
|---|---|
| F-Prime Capital | 8 |
| Optum Ventures | 6 |
| Blue Venture Funds | 5 |
| CVS Health Ventures | 5 |
| Y Combinator | 5 |
| Echo Health Ventures | 4 |
| General Catalyst | 4 |
| AlleyCorp | 3 |
Its portfolio companies
where they are based, and what their own sites showSite status
- Site answers6394%
- No longer answers00%
- Points to another company46%
- Parked or sold domain00%
A site that stops answering three checks in a row is counted as no longer answering; that is not proof of closure. A site that points to another company is often an acquisition.
Co-investor network
who it backs companies with, and who they back togetherCompare .406 Ventures head to head
portfolio size, rounds, entry stages, themes and the companies both backThree or more firms at once: portfolio overlap.
Recent portfolio activity
when companies last raised with .406 Ventures| Date | Company | Stage |
|---|---|---|
| 6 Oct 2026 | Series A Led | |
| 6 Oct 2026 | Series A | |
| 12 Aug 2026 | Series A | |
| 17 Jun 2026 | Series A | |
| 15 Jun 2026 | Series C+ | |
| 10 Jun 2026 | Seed Led | |
| 12 Feb 2026 | Round Led | |
| 16 Dec 2025 | Series A |
Round details for .406 Ventures
Amounts, full round histories and every co-investor in .406 Ventures' rounds are on Fundup AI. VCinfo covers investors and their portfolios.
Portfolio
67 companies checked against their own sites| Company | What it does | Themes | First round with it | Evidence |
|---|---|---|---|---|
| Abacus Insights provides a data platform for healthcare payers to connect and transform fragmented data into a single source of truth | Healthcare & Biotech | Portfolio page | ||
| AblePay makes paying out-of-pocket medical expenses easy and convenient for patients | Healthcare & Biotech | Portfolio page | ||
Healthcare & Biotech | Portfolio page | |||
| The company provides an online whiteboard for filmmaking teams to work with AI | Enterprise SoftwareMedia & Entertainment | Portfolio page | ||
| Arboretum partners with healthcare systems to implement genetic testing programs for various diseases | Healthcare & Biotech | Oct 2026Series A | Page + round | |
| AristaMD provides access to specialty care services, including virtual consultations and telehealth specialist panels, to help primary care physicians improve patient outcomes and reduce healthcare costs. | Healthcare & Biotech | Portfolio page | ||
| Ascellus provides behavioral health solutions for workers' compensation claims | Healthcare & Biotech | Portfolio page | ||
| Bedrock Data provides a platform for data security and AI risk management | CybersecurityAI & Machine Learning | Portfolio page | ||
| Portfolio page | ||||
| Better Life Partners provides treatment for addiction and mental health disorders, including medication, group therapy, and overall health care. | Healthcare & Biotech | Portfolio page | ||
| Business Intelligence Advisors provides behavioral analysis and investment research services to investors | FintechEducation | Portfolio page | ||
| Big Health provides digital mental health treatments for patients with insomnia and anxiety. | Healthcare & Biotech | Feb 2026Round | Page + round | |
| Bluebird Kids Health provides pediatric care services, including newborn care, well-checks, and sick visits. | Healthcare & Biotech | Portfolio page | ||
| Bobsled provides an operating system for data products | AI & Machine LearningFintech | Portfolio page | ||
| Claren Health helps patients understand their medical conditions and make informed decisions about their care. | Healthcare & Biotech | Portfolio page | ||
| The company provides a workspace for team-based agentic software development | AI & Machine LearningEnterprise Software | Portfolio page | ||
| Cortica specializes in evidence-based ABA therapy, speech therapy, occupational therapy, and more for children with autism spectrum disorder (ASD). | Healthcare & Biotech | Portfolio page | ||
| Corvus provides cyber insurance coverage and solutions to businesses. | CybersecurityFintech | Portfolio page | ||
| Disarray builds AI research agents for long-horizon autonomy over heterogeneous data | AI & Machine Learning | Portfolio page | ||
| The company provides virtual treatment for eating disorders. | Healthcare & Biotech | Portfolio page |
About this data
site last read 5 Nov 2026- Site
- 406ventures.com
- Last read
- 5 Nov 2026
- Watching since
- 5 Nov 2026
- Rounds since
- 11 Sept 2025
- Companies checked
- 67
Rates come from what VCinfo has observed since observation_start. Firms tend to remove companies that closed, so early rates understate reality. A company leaving a portfolio page does not mean it closed or exited. An unreachable site means our checks failed, nothing more.
Get .406 Ventures' profile as data
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