Investors / United States / First Spark Ventures
First Spark Ventures
Venture capital · Menlo Park, CA, United States · North America
First Spark Ventures is a Deep Tech venture capital fund that invests in startups with fundamental technological insights. It focuses on Advanced Compute, Digital Biology & Biotech, and CyberPhysical Systems.
Invests inAI & Machine LearningHealthcare & Biotech
In its own wordsdeep techadvanced computedigital biologybiotechcyberphysical systemsartificial intelligence
Your fit with First Spark Ventures
Four questions about your startup
See how your round matches what it backs, point by point.
Or find every investor that fitsFirst Spark Ventures lists 24 checked portfolio companies on its own site and is named in 5 funding rounds, 1 of them as lead. Its most frequent entry is Seed, 40% of the companies with a known first round. Its largest themes are AI & Machine Learning (37%), Healthcare & Biotech (34%) and Space & Defense (6%). 93% of its companies are based in United States. It invests most often alongside Creative Destruction Lab, Samsung NEXT and ARTIS.
Counts come from funding rounds that name First Spark Ventures, complete from mid-2025: earlier rounds appear only when they were reported later. Round amounts and full round histories are on Fundup AI.
Round figures show recent activity, not First Spark Ventures' whole history. Rounds on record name 5 companies; its own site lists 24. Funding rounds are complete from mid-2025, so counts and the yearly trend undercount a firm that invested before then. The portfolio, themes and places come from its own site and are not affected.
Entry stage
share of companies by the stage of its first roundShow as a table
| Value | |
|---|---|
| Pre-seed | 0% |
| Seed | 40% |
| Series A | 40% |
| Series B | 20% |
| Growth | 0% |
Activity by year
rounds it joined, last 10 yearsShow as a table
| Total | Rounds it led | |
|---|---|---|
| '17 | 0 | 0 |
| '18 | 0 | 0 |
| '19 | 0 | 0 |
| '20 | 0 | 0 |
| '21 | 0 | 0 |
| '22 | 0 | 0 |
| '23 | 0 | 0 |
| '24 | 0 | 0 |
| '25 | 3 | 1 |
| '26 | 2 | 0 |
Investor profile
percentile among all firmsShow as a table
| Measure | Percentile of all firms | Value |
|---|---|---|
| Portfolio size | 59th | 24 companies |
| Recent activity | 69th | 2 rounds in 12 months |
| Early stage | 66th | 40% of entries at pre-seed or seed |
| Evidence | 83th | 13% of companies confirmed by a round |
| Sector focus | 68th | 37% in its largest sector |
| Reach | 42th | 2 countries |
Investment themes
share of its checked companiesThis firmAll checked companies
Show as a table
| This firm | All checked companies | |
|---|---|---|
| AI & Machine Learning | 37% | 18% |
| Healthcare & Biotech | 34% | 15% |
| Space & Defense | 6% | 3% |
| Cybersecurity | 6% | 4% |
| Industrial & Manufacturing | 6% | 7% |
| Consumer | 3% | 3% |
| Media & Entertainment | 3% | 4% |
| E-commerce & Marketplaces | 3% | 6% |
Invests most often with
firms sharing its portfolio companiesShow as a table
| Share | |
|---|---|
| Creative Destruction Lab | 3 |
| Samsung NEXT | 3 |
| ARTIS | 2 |
| Collaborative Fund | 2 |
| Droia Ventures | 2 |
| Evolution VC Partners | 2 |
| Future Ventures | 2 |
| The Venture Collective | 2 |
Its portfolio companies
where they are based, and what their own sites showSite status
- Site answers24100%
- No longer answers00%
- Points to another company00%
- Parked or sold domain00%
A site that stops answering three checks in a row is counted as no longer answering; that is not proof of closure. A site that points to another company is often an acquisition.
Co-investor network
who it backs companies with, and who they back togetherAll co-investors or Compare portfolios with Creative Destruction Lab
Compare First Spark Ventures head to head
portfolio size, rounds, entry stages, themes and the companies both backThree or more firms at once: portfolio overlap.
Recent portfolio activity
when companies last raised with First Spark Ventures| Date | Company | Stage |
|---|---|---|
| 15 Jun 2026 | Seed | |
| 16 Mar 2026 | Series B | |
| 29 Oct 2025 | Seed Led | |
| 29 Oct 2025 | Series A | |
| 1 Aug 2025 | Series A |
Round details for First Spark Ventures
Amounts, full round histories and every co-investor in First Spark Ventures' rounds are on Fundup AI. VCinfo covers investors and their portfolios.
Portfolio
24 companies checked against their own sites| Company | What it does | Themes | First round with it | Evidence |
|---|---|---|---|---|
| Alljoined is creating a future where people can better understand themselves and connect with technology using advanced AI models that extract semantic content and thought patterns from brain signals | AI & Machine LearningHealthcare & Biotech | Portfolio page | ||
| Confidencial protects data end to end for various industries, including legal, pharma, and financial services. | CybersecurityAI & Machine Learning | Portfolio page | ||
| Curve Biosciences monitors chronic diseases using Whole-Body Intelligence models and blood tests. | Healthcare & Biotech | Oct 2025Series A | Page + round | |
| Endometrics develops a novel easy-to-use solution for early diagnosis of endometriosis | Healthcare & Biotech | Portfolio page | ||
| Figur8 provides lab-grade biomechanics data for precise assessments and personalized treatment plans for patients with musculoskeletal conditions | Healthcare & Biotech | Portfolio page | ||
| Flower builds the foundation for AI that is open, collaborative and fundamentally aligned with human progress. | AI & Machine Learning | Portfolio page | ||
| Fundamental Research Labs is building digital humans and AI that understand the fundamental value of a business. | AI & Machine LearningFintech | Aug 2025Series A | Page + round | |
| Inlyte Energy develops and manufactures iron-sodium batteries for various applications, including data centers, utilities, and commercial customers. | E-commerce & MarketplacesIndustrial & Manufacturing | Portfolio page | ||
| Inworld provides AI models and inference for consumer applications, including text-to-speech, speech-to-text, and speech-to-speech services. | AI & Machine LearningConsumer | Portfolio page | ||
| The company creates human cells and organoids using a precision engineering platform for in vitro modeling and cell therapies. | Healthcare & Biotech | Oct 2025Seed | Funding round | |
| Latent AI develops and provides an edge AI platform for various industries, including defense and enterprise, to enable autonomous operations and real-time intelligence. | AI & Machine LearningCybersecurity | Portfolio page | ||
| Nimble develops and uses small intestine sampling technology to collect and analyze multi-omic datasets from the GI tract | Healthcare & Biotech | Portfolio page | ||
| The company develops and manufactures AI hardware, including custom silicon and reference systems, to improve energy efficiency in AI inference. | AI & Machine LearningSpace & Defense | Portfolio page | ||
| Oath provides patients with access to high quality, lower cost surgical care in outpatient settings | Healthcare & Biotech | Portfolio page | ||
| Radical Numerics is a next-generation AI lab building toward general biological intelligence | Healthcare & BiotechAI & Machine Learning | Jun 2026Seed | Page + round | |
| Simulon creates a camera application that allows users to create and capture virtual objects in the real world. | Media & EntertainmentAI & Machine Learning | Portfolio page | ||
| SoloPulse develops systems that convert invisible RF signals into persistent, actionable data for global operations | AI & Machine LearningAI & Machine Learning | Portfolio page | ||
| Synth Labs is building the next generation of AI alignment and post-training technologies to create more capable and trustworthy AI systems | AI & Machine Learning | Portfolio page | ||
| Tidal Metals extracts magnesium from seawater using electricity and new patented technologies | Industrial & Manufacturing | Portfolio page | ||
| Unnatural Products pioneers the development of synthetic macrocyclic peptides | Healthcare & Biotech | Portfolio page |
About this data
site last read 5 Nov 2026- Site
- firstsparkventures.com
- Last read
- 5 Nov 2026
- Watching since
- 5 Nov 2026
- Rounds since
- 1 Aug 2025
- Companies checked
- 24
Rates come from what VCinfo has observed since observation_start. Firms tend to remove companies that closed, so early rates understate reality. A company leaving a portfolio page does not mean it closed or exited. An unreachable site means our checks failed, nothing more.
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