Investors / United States / Lightstone Ventures
Lightstone Ventures
Venture capital · Boston, MA, United States · North America
Lightstone Ventures is a life science investment firm founded in 2012 that backs biotech and medtech companies. It works hands-on with founders to build companies, with offices in the U.S. and Ireland.
Invests inHealthcare & Biotech
In its own wordsbiotechmedtechtherapeuticscnsimmunologyoncology
Your fit with Lightstone Ventures
Four questions about your startup
See how your round matches what it backs, point by point.
Or find every investor that fitsLightstone Ventures lists 39 checked portfolio companies on its own site and is named in 7 funding rounds. Its most frequent entry is Series A, 50% of the companies with a known first round. Its largest themes are Healthcare & Biotech (95%), Industrial & Manufacturing (3%) and Space & Defense (3%). 63% of its companies are based in United States. It invests most often alongside NEA, Canaan and Foresite Capital.
Counts come from funding rounds that name Lightstone Ventures, complete from mid-2025: earlier rounds appear only when they were reported later. Round amounts and full round histories are on Fundup AI.
Round figures show recent activity, not Lightstone Ventures' whole history. Rounds on record name 6 companies; its own site lists 39. Funding rounds are complete from mid-2025, so counts and the yearly trend undercount a firm that invested before then. The portfolio, themes and places come from its own site and are not affected.
Entry stage
share of companies by the stage of its first roundLightstone Ventures does not state its stages on its site, so only what it does is shown.
Show as a table
| Value | |
|---|---|
| Pre-seed | 0% |
| Seed | 0% |
| Series A | 50% |
| Series B | 33% |
| Growth | 17% |
Activity by year
rounds it joined, last 10 yearsShow as a table
| Total | Rounds it led | |
|---|---|---|
| '17 | 0 | 0 |
| '18 | 0 | 0 |
| '19 | 0 | 0 |
| '20 | 0 | 0 |
| '21 | 0 | 0 |
| '22 | 0 | 0 |
| '23 | 0 | 0 |
| '24 | 0 | 0 |
| '25 | 5 | 0 |
| '26 | 2 | 0 |
Investor profile
percentile among all firmsShow as a table
| Measure | Percentile of all firms | Value |
|---|---|---|
| Portfolio size | 75th | 37 companies |
| Recent activity | 76th | 3 rounds in 12 months |
| Early stage | 54th | 0% of entries at pre-seed or seed |
| Evidence | 84th | 14% of companies confirmed by a round |
| Sector focus | 97th | 95% in its largest sector |
| Reach | 88th | 7 countries |
Invests most often with
firms sharing its portfolio companiesShow as a table
| Share | |
|---|---|
| NEA | 9 |
| Canaan | 4 |
| Foresite Capital | 4 |
| Arboretum Ventures | 3 |
| Dolby Family Ventures | 3 |
| Elevage Medical Technologies | 3 |
| RA Capital | 3 |
| Abingworth | 2 |
Its portfolio companies
where they are based, and what their own sites showSite status
- Site answers3179%
- No longer answers00%
- Points to another company821%
- Parked or sold domain00%
A site that stops answering three checks in a row is counted as no longer answering; that is not proof of closure. A site that points to another company is often an acquisition.
Investment themes
share of its checked companiesThis firmAll checked companies
Show as a table
| This firm | All checked companies | |
|---|---|---|
| Healthcare & Biotech | 95% | 15% |
| Industrial & Manufacturing | 3% | 7% |
| Space & Defense | 3% | 3% |
Co-investor network
who it backs companies with, and who they back togetherCompare Lightstone Ventures head to head
portfolio size, rounds, entry stages, themes and the companies both backThree or more firms at once: portfolio overlap.
Recent portfolio activity
when companies last raised with Lightstone Ventures| Date | Company | Stage |
|---|---|---|
| 22 Jul 2026 | Series B | |
| 12 May 2026 | Series C+ | |
| 10 Dec 2025 | Series A | |
| 30 Sept 2025 | Series A | |
| 9 Sept 2025 | Series A | |
| 13 Aug 2025 | Series B | |
| 7 Aug 2025 | Series B |
Round details for Lightstone Ventures
Amounts, full round histories and every co-investor in Lightstone Ventures' rounds are on Fundup AI. VCinfo covers investors and their portfolios.
Portfolio
39 companies checked against their own sites| Company | What it does | Themes | First round with it | Evidence |
|---|---|---|---|---|
Healthcare & Biotech | Portfolio page | |||
| Alchemab Therapeutics develops antibody therapeutics for hard to treat diseases using the immune system | Healthcare & Biotech | Sept 2025Series A | Page + round | |
| Allay Therapeutics develops technology for localized pain management. | Healthcare & Biotech | Portfolio page | ||
| ALX Oncology is a clinical-stage biopharmaceutical company advancing a pipeline of novel therapies designed to treat cancer and extend patients' lives. | Healthcare & Biotech | Portfolio page | ||
| Amber Therapeutics is developing the first adaptive neuromodulation therapy to treat women suffering with mixed urinary incontinence | Healthcare & Biotech | Portfolio page | ||
| Apreo Health develops a bronchoscopic treatment for severe emphysema using a self-expanding nitinol scaffold to improve lung function and breathing capacity. | Healthcare & Biotech | Aug 2025Series B | Funding round | |
| Ardian is a global diversified private markets firm providing investment solutions and customized strategies. | FintechReal Estate & Construction | Portfolio page | ||
| Atsena Therapeutics is a clinical-stage gene therapy company developing treatments for inherited retinal diseases. | Healthcare & Biotech | Portfolio page | ||
| Bonito Biosciences is building a data foundation for programmable oligonucleotide delivery | Healthcare & Biotech | Portfolio page | ||
| Cala Health develops and provides a device with TAPS therapy to aid in the temporary relief of hand tremors in adults with essential tremor. | Healthcare & Biotech | Portfolio page | ||
| Carrick Therapeutics is a clinical-stage biopharmaceutical company focused on building the future of oncological therapy to improve patient outcomes. | Healthcare & Biotech | Portfolio page | ||
| Cerevance develops therapies for neurodegenerative disorders, including Parkinson's disease. | Healthcare & Biotech | May 2026Series C+ | Page + round | |
| Contego Medical develops and manufactures medical devices for carotid and peripheral vascular procedures. | Healthcare & Biotech | Portfolio page | ||
| Crystalys Therapeutics develops new therapeutics to address unmet medical needs, specifically for people living with gout. | Healthcare & Biotech | Sept 2025Series A · 2 rounds | Page + round | |
| Cyteir is a clinical-stage oncology company that is focused on the development of an oral investigational drug that inhibits monocarboxylate transporters. | Healthcare & Biotech | Portfolio page | ||
Healthcare & Biotech | Portfolio page | |||
| Fire1 develops a medical device for heart failure management | Healthcare & Biotech | Portfolio page | ||
Healthcare & Biotech | Portfolio page | |||
| Portfolio page | ||||
| MediSix Therapeutics is a company developing innovative T-cell therapies with its proprietary PEBL technology platform | Healthcare & Biotech | Portfolio page |
About this data
site last read 5 Nov 2026- Site
- lightstonevc.com
- Last read
- 5 Nov 2026
- Watching since
- 5 Nov 2026
- Rounds since
- 7 Aug 2025
- Companies checked
- 39
Rates come from what VCinfo has observed since observation_start. Firms tend to remove companies that closed, so early rates understate reality. A company leaving a portfolio page does not mean it closed or exited. An unreachable site means our checks failed, nothing more.
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