Investors / United States / Spero Ventures
Spero Ventures
Venture capital · Burlingame, CA, United States · North America
Spero Ventures is a boutique venture capital firm that backs founders using technology to address large challenges. It leads and co-leads seed and Series A rounds and works closely with a concentrated portfolio of companies.
Invests inHealthcare & BiotechEducation
In its own wordshealthsustainabilityclimateenergyhealthcarepurpose-driven
Your fit with Spero Ventures
Four questions about your startup
See how your round matches what it backs, point by point.
Or find every investor that fitsSpero Ventures lists 28 checked portfolio companies on its own site and is named in 9 funding rounds, 3 of them as lead. Its most frequent entry is Seed, 44% of the companies with a known first round. Its largest themes are Healthcare & Biotech (27%), Education (18%) and AI & Machine Learning (14%). 95% of its companies are based in United States. It invests most often alongside Scribble Ventures, Standish Spring Investments and Y Combinator.
Counts come from funding rounds that name Spero Ventures, complete from mid-2025: earlier rounds appear only when they were reported later. Round amounts and full round histories are on Fundup AI.
Round figures show recent activity, not Spero Ventures' whole history. Rounds on record name 9 companies; its own site lists 28. Funding rounds are complete from mid-2025, so counts and the yearly trend undercount a firm that invested before then. The portfolio, themes and places come from its own site and are not affected.
Entry stage
share of companies by the stage of its first roundShow as a table
| Value | |
|---|---|
| Pre-seed | 0% |
| Seed | 44% |
| Series A | 44% |
| Series B | 11% |
| Growth | 0% |
Activity by year
rounds it joined, last 10 yearsShow as a table
| Total | Rounds it led | |
|---|---|---|
| '17 | 0 | 0 |
| '18 | 0 | 0 |
| '19 | 0 | 0 |
| '20 | 0 | 0 |
| '21 | 0 | 0 |
| '22 | 0 | 0 |
| '23 | 1 | 1 |
| '24 | 0 | 0 |
| '25 | 4 | 1 |
| '26 | 4 | 1 |
Investor profile
percentile among all firmsShow as a table
| Measure | Percentile of all firms | Value |
|---|---|---|
| Portfolio size | 65th | 28 companies |
| Recent activity | 82th | 4 rounds in 12 months |
| Early stage | 67th | 44% of entries at pre-seed or seed |
| Evidence | 96th | 29% of companies confirmed by a round |
| Sector focus | 43th | 27% in its largest sector |
| Reach | 42th | 2 countries |
Investment themes
share of its checked companiesThis firmAll checked companies
Show as a table
| This firm | All checked companies | |
|---|---|---|
| Healthcare & Biotech | 27% | 15% |
| Education | 18% | 7% |
| AI & Machine Learning | 14% | 18% |
| Industrial & Manufacturing | 9% | 7% |
| E-commerce & Marketplaces | 9% | 6% |
| Fintech | 7% | 12% |
| Enterprise Software | 5% | 8% |
| Human Resources | 5% | 1% |
Invests most often with
firms sharing its portfolio companiesShow as a table
| Share | |
|---|---|
| Scribble Ventures | 3 |
| Standish Spring Investments | 3 |
| Y Combinator | 3 |
| City Light | 2 |
| Inspired Capital | 2 |
| Override | 2 |
| WovenEarth Ventures | 2 |
| 111° West Capital | 1 |
Its portfolio companies
where they are based, and what their own sites showSite status
- Site answers28100%
- No longer answers00%
- Points to another company00%
- Parked or sold domain00%
A site that stops answering three checks in a row is counted as no longer answering; that is not proof of closure. A site that points to another company is often an acquisition.
Co-investor network
who it backs companies with, and who they back togetherAll co-investors or Compare portfolios with Scribble Ventures
Compare Spero Ventures head to head
portfolio size, rounds, entry stages, themes and the companies both backThree or more firms at once: portfolio overlap.
Recent portfolio activity
when companies last raised with Spero Ventures| Date | Company | Stage |
|---|---|---|
| 29 Sept 2026 | Series B | |
| 25 Aug 2026 | Series A | |
| 13 Aug 2026 | Seed Led | |
| 8 Apr 2026 | Series A | |
| 6 Nov 2025 | Seed | |
| 5 Sept 2025 | Series A | |
| 5 Aug 2025 | Seed Led | |
| 1 Jul 2025 | Series A |
Round details for Spero Ventures
Amounts, full round histories and every co-investor in Spero Ventures' rounds are on Fundup AI. VCinfo covers investors and their portfolios.
Portfolio
28 companies checked against their own sites| Company | What it does | Themes | First round with it | Evidence |
|---|---|---|---|---|
| The company connects backup generators to energy markets to turn them into revenue-generating assets. | EducationIndustrial & Manufacturing | Aug 2026Seed | Funding round | |
| Allie AI provides an AI platform for manufacturing operations, including production optimization and predictive maintenance. | Industrial & Manufacturing | Nov 2025Seed | Page + round | |
| Aralez Bio produces noncanonical amino acids used in medicine | Healthcare & Biotech | Portfolio page | ||
| Portfolio page | ||||
| Canopy provides a safety platform for hospitals using real-time location systems (RTLS) technology. | Healthcare & Biotech | Portfolio page | ||
| Clarity provides air quality monitoring systems and solutions | Healthcare & BiotechIndustrial & Manufacturing | Portfolio page | ||
| The company provides a workforce enablement system with various products for learning, performance management, and employee engagement | EducationHuman Resources | Portfolio page | ||
| The company develops and manufactures autonomous inventory management systems for warehouses. | Robotics & HardwareAI & Machine Learning | Aug 2026Series A | Page + round | |
| Eli automates the financial workflows for America's energy upgrade, including eligibility, verification, compliance, and payments for energy programs and contractors. | FintechEducation | Portfolio page | ||
| Euclid Power develops solutions for renewable energy project development | EducationFintech | Sept 2025Series A | Page + round | |
| Gencove provides genetic insights and health information through DNA sequencing and analysis. | Healthcare & Biotech | Portfolio page | ||
| The company provides AI-powered interview scheduling tools for recruiters and employers. | AI & Machine LearningHuman Resources | Portfolio page | ||
| Huckleberry pairs pediatric sleep experts with AI to create a custom sleep plan for families | Healthcare & Biotech | Portfolio page | ||
| Hyro provides a care communications platform for healthcare providers to manage patient interactions and workflows. | Healthcare & BiotechAI & Machine Learning | Portfolio page | ||
| Juno provides child disability insurance as an employee benefit to support working parents if a child develops a severe illness or disability. | Healthcare & BiotechFintech | Portfolio page | ||
| Mobius Materials operates a B2B marketplace for buying and selling electronic components | E-commerce & MarketplacesIndustrial & Manufacturing | May 2023Seed | Page + round | |
| Oova develops and sells at-home hormone monitoring kits for fertility and perimenopause tracking | Healthcare & Biotech | Portfolio page | ||
| The company provides artificial intelligence solutions for pharmaceutical formulation development | Healthcare & BiotechAI & Machine Learning | Portfolio page | ||
| The company builds and sells AI agents for various business applications. | AI & Machine LearningEnterprise Software | Portfolio page | ||
| Singularity connects generation data, program operations, and reporting obligations for clean energy and emissions programs | EducationE-commerce & Marketplaces | Portfolio page |
About this data
site last read 5 Nov 2026- Site
- spero.vc
- Last read
- 5 Nov 2026
- Watching since
- 5 Nov 2026
- Rounds since
- 16 May 2023
- Companies checked
- 28
Rates come from what VCinfo has observed since observation_start. Firms tend to remove companies that closed, so early rates understate reality. A company leaving a portfolio page does not mean it closed or exited. An unreachable site means our checks failed, nothing more.
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