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Investors / United States / UPMC Enterprises

UPMC Enterprises

Corporate VC · Pittsburgh, PA, United States · North America

upmc.comTakes pitches from founders

UPMC Enterprises is the innovation, commercialization, and venture capital arm of UPMC, a health care provider and insurer based in Pittsburgh, PA. It invests financial and intellectual capital in and forms companies developing health care technology, diagnostics, and therapeutics.

Invests inHealthcare & Biotech

In its own wordshealthcaredigital healthdiagnosticstherapeuticsbiotechvalue-based care

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64portfolio companies
10funding rounds on record3 led
5rounds, last 12 months
$20M to $100Mtypical round it comes in at
Series Amost frequent entry

UPMC Enterprises lists 64 checked portfolio companies on its own site and is named in 10 funding rounds, 3 of them as lead. Its most frequent entry is Series A, 50% of the companies with a known first round. Its largest themes are Healthcare & Biotech (94%), AI & Machine Learning (3%) and Fintech (2%). 95% of its companies are based in United States. It invests most often alongside First Trust Capital Partners, GV and MemorialCare Innovation Fund.

Counts come from funding rounds that name UPMC Enterprises, complete from mid-2025: earlier rounds appear only when they were reported later. Round amounts and full round histories are on Fundup AI.

Round figures show recent activity, not UPMC Enterprises' whole history. Rounds on record name 10 companies; its own site lists 64. Funding rounds are complete from mid-2025, so counts and the yearly trend undercount a firm that invested before then. The portfolio, themes and places come from its own site and are not affected.

Entry stage

share of companies by the stage of its first round
Show as a table
Share of companies by the stage of the firm's first round
Value
Pre-seed0%
Seed10%
Series A50%
Series B20%
Growth20%

Activity by year

rounds it joined, last 10 years
Show as a table
Funding rounds per year
TotalRounds it led
'1700
'1800
'1900
'2000
'2100
'2200
'2300
'2411
'2541
'2651

Investor profile

percentile among all firms
Portfolio size: 64 companiesRecent activity: 5 rounds in 12 monthsEarly stage: 10% of entries at pre-seed or seedEvidence: 16% of companies confirmed by a roundSector focus: 94% in its largest sectorReach: 3 countriesPortfolio size89th pctRecent activity86th pctEarly stage55th pctEvidence87th pctSector focus96th pctReach58th pct
This firmMedian of all firms
Show as a table
UPMC Enterprises compared with all firms
MeasurePercentile of all firmsValue
Portfolio size89th64 companies
Recent activity86th5 rounds in 12 months
Early stage55th10% of entries at pre-seed or seed
Evidence87th16% of companies confirmed by a round
Sector focus96th94% in its largest sector
Reach58th3 countries

Invests most often with

firms sharing its portfolio companies
Show as a table
Co-investors
Share
First Trust Capital Partners5
GV4
MemorialCare Innovation Fund4
Foresite Capital3
Transformation Capital3
5AM Ventures2
Asset Management Company2
Blue Venture Funds2

All co-investors

Its portfolio companies

where they are based, and what their own sites show

Site status

  • Site answers6297%
  • No longer answers00%
  • Points to another company23%
  • Parked or sold domain00%

A site that stops answering three checks in a row is counted as no longer answering; that is not proof of closure. A site that points to another company is often an acquisition.

Investment themes

share of its checked companies

This firmAll checked companies

Show as a table
Investment themes
This firmAll checked companies
Healthcare & Biotech94%15%
AI & Machine Learning3%18%
Fintech2%12%
Media & Entertainment2%4%

Compare UPMC Enterprises head to head

portfolio size, rounds, entry stages, themes and the companies both back

Three or more firms at once: portfolio overlap.

Recent portfolio activity

when companies last raised with UPMC Enterprises
DateCompanyStage
16 Oct 2026Estuary Bioestuarybio.comSeries A
29 Sept 2026ai3.Bioai3.bioSeries A Led
12 May 2026Cerevancecerevance.comSeries C+
26 Feb 2026Braincheckbraincheck.comSeries A
12 Jan 2026Precede Biosciencesprecede.bioSeries B
11 Sept 2025Penguin AIpenguinai.coSeries A
10 Sept 2025Optain Healthoptainhealth.comSeries A
31 Jul 2025Ultromicsultromics.comSeries C+

Round details for UPMC Enterprises

Amounts, full round histories and every co-investor in UPMC Enterprises' rounds are on Fundup AI. VCinfo covers investors and their portfolios.

See rounds on Fundup AI →

Portfolio

64 companies checked against their own sites
CompanyWhat it doesThemesFirst round with itEvidence
Abridgeabridge.com · United StatesAbridge develops and provides generative AI for clinical conversations and documentation in healthcare.
Healthcare & BiotechAI & Machine Learning
Portfolio page
ai3.Bioai3.bio · United StatesThe company develops therapies that target disease-causing T cells to treat autoimmune diseases.
Healthcare & Biotech
Sept 2026Series APage + round
alungalung.com · United Kingdom
Healthcare & Biotech
Portfolio page
Arkos Healtharkoshealth.comArkos Health partners with payers and providers to transform their healthcare systems into value-based care delivery systems
Healthcare & Biotech
Portfolio page
Arrive Healtharrivehealth.com · United StatesArrive Health works to make care decisions better for patients and providers, improving affordability, access, and outcomes
Healthcare & Biotech
Portfolio page
Astrataastrata.co · United StatesAstrata provides healthcare software solutions
Healthcare & Biotech
Portfolio page
Avista Therapeuticsavistatx.comAvista Therapeutics develops gene therapy using advanced AI platforms and capsid design
Healthcare & Biotech
Portfolio page
Braincheckbraincheck.com · United StatesBraincheck provides a digital platform for cognitive assessment and care planning
Healthcare & Biotech
Feb 2026Series APage + round
Butterfly Networkbutterflynetwork.comButterfly brings the power of ultrasound into your assessment, diagnosis and treatment
Healthcare & Biotech
Portfolio page
CarePathRxcarepathrxllc.comCarepathRx partners with health systems, hospitals, physicians, and pharmacies to provide pharmacy care
Healthcare & Biotech
Portfolio page
Carta Healthcarecarta.healthcare · United StatesCarta Healthcare develops and provides an AI platform for managing and analyzing clinical data for healthcare organizations.
Healthcare & Biotech
May 2025Series BPage + round
Cavuluscavulus.com · United StatesCavulus provides technology and advisory services for health plans, including Medicare Advantage, Supplemental, ACA and Marketplace growth.
Healthcare & Biotech
Portfolio page
Cerevancecerevance.com · United StatesCerevance develops therapies for neurodegenerative disorders, including Parkinson's disease.
Healthcare & Biotech
May 2026Series C+Page + round
Clearsenseclearsense.com · United StatesClearsense provides a healthcare data platform that integrates and manages data from disparate sources
Healthcare & Biotech
Portfolio page
CodeBioTxcodebiotx.com · United StatesCode Biotherapeutics is developing precision genetic medicines to treat life-threatening diseases.
Healthcare & Biotech
Portfolio page
Edifecsedifecs.com · United StatesEdifecs delivers connected, accurate, and efficient healthcare through market-leading interoperability, payment integrity, and health enablement infrastructure
Healthcare & Biotech
Portfolio page
Elektra Healthelektrahealth.com · United StatesElektra Health provides menopause care and support through telemedicine, education, and community services.
Healthcare & Biotech
Feb 2024SeedPage + round
Estuary Bioestuarybio.com · United StatesEstuary Bio is developing gene therapies to treat autosomal dominant polycystic kidney disease (ADPKD)
Healthcare & Biotech
Oct 2026Series APage + round
EVisitevisit.comeVisit helps healthcare delivery systems coordinate services and improve access, efficiency, and outcomes through digital platforms and technology.
Healthcare & Biotech
Portfolio page
Generiangenerian.com
Portfolio page

About this data

site last read 5 Nov 2026
The homepage of UPMC Enterprises, as last read
upmc.com as VCinfo last read it
Site
upmc.com
Last read
5 Nov 2026
Watching since
6 Nov 2026
Rounds since
21 Feb 2024
Companies checked
64

Rates come from what VCinfo has observed since observation_start. Firms tend to remove companies that closed, so early rates understate reality. A company leaving a portfolio page does not mean it closed or exited. An unreachable site means our checks failed, nothing more.

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